what yoshinory ohsumi said on autophagy

Yoshinori Ohusumi said on autophagy

Yoshinori Ohsumi is a professor at the Tokyo Institute of Technology's Innovative Research Institute. He received the Kyoto Prize for basic sciences in 2012, the Nobel Prize in physiology or medicine in 2016, and the revolutionary prize 2017 in life sciences for his discoveries on the mechanisms of autophagy.

Autophagy

I try to give a summary of what Yoshinori Ohosumi said about autophagy at the Tokyo Institute of Technology, Japan, Oct 2017.

When I was in high school, I was interested in chemistry, so I want to be a chemist when I entered the University of Tokyo in the sixties, there was a wonderful time for the gesture establishing molecular biology.

I always started my conference with this question how many red blood cells are made per second in an average human body, it is millions if there is no degradation of old cells there will be an overload which would be harmful to our body.

Example: We make about two to three hundred grams of protein every day, but we take 70 to 80 grams of protein as food and if we can get these amino acid proteins to turn into an amino acid that's just 70 grams not enough to make this type of protein, so just that simple number suggests that the proteins in our body break down and that most of them in acid come from there our own protein, so our system is adjusted to the state of equilibrium of their synthesis and degradation of proteins, therefore, in fact, life is an equal state between protein synthesis and protein degradation.

Researcher Christian de Duve.

Autophagy pioneer

Researcher Christian de Duve found that lysosomes that contain a small enzyme inside, then search for a group including an analyzer, Christian deduces how proteins enter the lysosome, and they discovered that they have named their own site Transfer of Erick protein in a vacuum to the lysosome, which means a process of self-feeding.

Autophagy is a unique system of degrading the whole organelle.

Tow majors roles of autophagy:

1) Nutrition and recycling.

2) Elimination of excessive or harmful
materials. (fasting)

The study of ATG proteins works during the formation of autophagosomes.

18 ATG proteins required for autophagosome formation.
ATG genes a set of genes encoding machinery essential for the unique membrane dynamics of autophagosome formation.

Looking back on 27 years of autophagy research:

— A long and winding path with many accidents and wonderful encounters.

— Curiosity-driven research, according to my own interest and concern by enjoying experiments.

All of my work was just a curiously sought cure I never thought that filled autophagy was linked to cancer or to many types of illnesses out there, this movie is now very popular in automotive udgie research, so I want to focus on curiosity-driven research is very important.

That's all.